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Through the use of SDS-PAGE and nano-LC paired Orbitrap LC-MS/MS analyses, we identified, the very first time, that the main DNA-cross-linked proteins in HeLa cells confronted with a methylating broker (methylmethanesulfonate) or hydroxyl free-radicals tend to be transcription-associated proteins. In specific, histone H2B3B and poly(rC) binding protein 2 had been identified as more regular DPC-forming proteins.Designing supramolecular architectures with unusual geometries embedded with
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