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It is impossible to do justice in one review article to a researcher of the stature of Christopher Dobson. His career spanned almost five decades, resulting in more than 870 publications and a legacy that will continue to influence the lives of many for decades to come. In this review, I have attempted to capture Chris's major contributions his early work, dedicated to understanding protein folding mechanisms; his collaborative work with physicists to understand the process of protein aggregation; and finally, his later career in which
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