https://www.selleckchem.com/pr....oducts/trc051384.htm
Facioscapulohumeral dystrophy (FSHD) is caused by mutations leading to the aberrant expression of the DUX4 transcription factor in muscles. DUX4 was proposed to induce cell death, but the involvement of different death pathways is still discussed. A possible pro-apoptotic role of DUX4 was proposed, but as FSHD muscles are characterized by necrosis and inflammatory infiltrates, non-apoptotic pathways may be also involved. We explored DUX4-mediated cell death by focusing on the role of one regulated necrosis pathway called necroptosis,
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