https://www.selleckchem.com/pr....oducts/CP-690550.htm
We hope this article can provide a timely and valuable reference for researchers interested in synthetic macrocycles and porous materials.An efficient enantioselective reaction between ketones and 3-hydroxyisoindolinones is described. In a reaction catalyzed by a chiral phosphoric acid, a broad range of ketones and in situ generated ketimines afforded isoindolinone derivatives comprising a tetrasubstituted stereocenter in high yields and enantioselectivities. The developed methodology is also suitable for the construction of compounds
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