https://www.selleckchem.com/pr....oducts/ferrostatin-1
Traditional monolayer culture fails to fully recapitulate the in vivo environment of connective tissue cells such as the fibroblast. When cultured on stiff two-dimensional plastic, fibroblasts become highly proliferative forming broad lamellipodia and stress fibres. Conversely, in different 3D culture systems fibroblasts have displayed a diverse array of features; from an 'activated' phenotype like that observed in 2D cultures and by myofibroblasts, to a quiescent state that likely better represents in vivo fibroblasts at rest. To
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