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011 and 0.009, respectively). These three genotypes were also linked to increased Hostility in the patients (FDR-q 0.05). Remarkably, a proximal area of the CNR1 gene locus (positions 88,143,916-88,149,832) correlated with PSDI, Hostility, Asceticism and EDI-2 total scores after correcting by multiple testing (FDR-q 0.05 in all instances). Finally, significant CNR1/CNR2 epistasis was observed in relation to Hostility (p 0.01) and Maturity Fears (p 0.001). The CNR1 and CNR2 genes, coding for cannabinoid receptors, may c
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