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LC pups have lower leptin receptor expression at birth and lower energy expenditure and activity during adulthood. CONCLUSION Choline content of diets that are consumed by rats during pregnancy affects the later-life phenotype of offspring, associated with altered in utero programing of hypothalamic food intake regulation. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Two new quinoline alkaloids, aaptolines A ( 1 ) and B ( 2 ) were isolated from the marine sponge Aaptos aaptos . Their structures were determined by HRESIMS data,
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