https://www.selleckchem.com/pr....oducts/pamapimod-r-1
An intriguing local epithelial enzyme contribution to renal medullary urea accumulation and ischemic tolerance was uncovered in a study by Ansermet et al published in the present issue of Acta Physiologica.1 It was shown in vivo in mice with tubular epithelial-specific deletion of the enzyme L-arginase type-2 (ARG2) that ARG2 contributed to medullary urea accumulation, through its hydrolysis of L-arginine into urea and L-ornithine, and to tissue protection after ischemia-reperfusion injury. The ability of the S3 segme
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