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OBJECTIVE To investigate current Down syndrome live birth and death rates, and childhood hospitalisations, compared with peers. SETTING General community. PARTICIPANTS All live births with Down syndrome, 1990-2015, identified via Scottish regional cytogenetic laboratories, each age-sex-neighbourhood deprivation matched with five non-Down syndrome controls. Record linkage to Scotland's hospital admissions and death data. PRIMARY OUTCOME HRs comparing risk of first hospitalisation (any and emergency), readmission for children with Down syn
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