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OBJECTIVE To investigate the effects of the Traditional Chinese Medicine Qishan granules (TCM Qishan) on glucose and lipid metabolism, plasma adiponectin, and insulin resistance (IR) in a rat model of prediabetes. METHODS A prediabetic rat model was established by high-fat diet-feeding. Sugar-free Qishan granules, rosiglitazone, or no treatment were then administered for 10 weeks, after which body mass, fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPG), hemoglobin A1c (HbA1c), fasting insulin (FINS), 2-h postprandial ins
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