https://www.selleckchem.com/pr....oducts/Rapamycin.htm
Atrial KCNN2 and KCNN3 expression was reduced in AF/HF patients and in a corresponding pig model. HDAC2 displayed significant downregulation in humans and a tendency towards reduced expression in right atrial tissue of pigs. Tachypacing recapitulated downregulation of Kcnn2/K 2.2, Kcnn3/K 2.3 and Hdac2/HDAC2, indicating that high atrial rates trigger epigenetic remodeling mechanisms. Finally, knock-down of Hdac2 in vitro reduced Kcnn3/K 2.3 expression. KCNN2/3 and HDAC2 expression is suppressed in AF complicated by HF. Hdac2 directly
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