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030-0.055,-0.005) from week 4; lower permeability k from week 18 (-0.954-1.339,-0.569); higher cartilage T2 values (1.803 1.504, 2.102) reflecting collagen loss beginning at week 10. For the PRP treatment group, subchondral bone marrow A and cartilage T2 decreased from week 10. Histological results confirmed and were correlated with the MRI findings. Subchondral hyper-perfusion plays a vital role in the pathogenesis of OA and was associated with cartilage degeneration. The efficacy of PRP can be observed from reduced perfusion and MRI T2
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