https://www.selleckchem.com/pr....oducts/ph-797804.htm
The anatomic analysis uncovered that decreasing the constitutive activity of DRD1 by its inverse agonists promoted the NSCs proliferation and maintenance that led to hindered cortical neurogenesis. Further mechanistic studies revealed that the PKC-CBP pathway was involved in the regulation by DRD1. Thus, our findings indicate that the constitutive activity of DRD1 and possibly other GPCRs plays an important role in the development of human nervous system. ©2020 The Authors. Stem Cells published by Wiley Periodicals, Inc. on behalf of
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