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ataset. 4 Technical Efficacy Stage 5. 4 Technical Efficacy Stage 5. Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of effect of lokivetmab (Cytopoint) in the IL-31-induced pruritus model. Twenty-four purpose-bred beagle dogs (neutered males, spayed and intact females) 1.
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