https://www.selleckchem.com/ALK.html
Aim To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials methods We utilized Monte Carlo Expectation-Maximization algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and to estimate their associations with phenotypes free of confounding by cell type proportions. Results Simulations showed reliable performance of the method under various settings including when the cell type is rare. Application to a real da
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