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On day 4, automobile, THC, or CBD ended up being administered and allodynia, hyperalgesia, weight-bearing, locomotor activity, and hindpaw edema had been evaluated 0.5-4 h post-injection. In Experiment 2, CFA- or mineral oil (control)-treated rats got vehicle, THC (2.0 mg/kg), or CBD (10 mg/kg) in much the same as in Experiment 1. Four-h post-injection on day 4, serum examples had been taken for analysis of cytokines recognized to affect inflammatory pain interleukin (IL)-1β, IL-6, IL-10, interfero
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