https://www.selleckchem.com/pr....oducts/b102-parp-hda
Clinical induction liability is assessed with human hepatocytes. However, underpredictions in the magnitude of clinical induction have been reported. Unfortunately, in vivo studies in animals do not provide additional insight due to species differences in drug metabolizing enzymes and their regulatory pathways. To circumvent this limitation, transgenic animals expressing human orthologues were developed. The aim of this work was to investigate the utility of mouse model expressing human orthologues of PXR, CAR and CYP3A4/7 (
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