https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
The TP53 gene encodes the tumor suppressor p53 which is functionally inactivated in many human cancers. Numerous studies suggested that 3'UTR-mediated p53 expression regulation plays a role in tumorigenesis and could be exploited for therapeutic purposes. However, these studies did not investigate post-transcriptional regulation of the native TP53 gene. Here, we used CRISPR/Cas9 to delete the human and mouse TP53/Trp53 3'UTRs while preserving endogenous mRNA processing. This revealed that the endogenous 3'UTR is not involve
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