https://www.selleckchem.com/pr....oducts/Cryptotanshin
The key genes and pathways in P.gingivalis-infected macrophages were explored by RNA sequencing. The protein level was investigated by Western blotting. Porphyromonas gingivalis increases foam cells formation and upregulates the expression of LIMP2 in foam cells. The knockdown of limp2 decreases the number of foam cells and increases cholesterol export, which is related to lysosomal functions. In addition, the interaction between LIMP2 and caveolin-1(CAV1) might contribute to this process, and NF-κB and JNK activity is required
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