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down-regulation of DNA repair protein RAD51 homolog 1 (RAD51), thus showing deficiency in DNA harm fix. Over-expression of ELF3 could up-regulate phosphorylation of AKT (Protein kinase , while knock down of ELF3 regulated homologous recombination-mediated DNA restoration Knock down of ELF3 disclosed homologous recombination deficiency via AKT signaling path, and artificial lethality with ELF3 inhibition and PARP inhibitor indicated the clinical significance of P
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