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This would cause a more prominent immune reaction to antigens. Based on these findings, we suggest that 13-cRA may have a sensitization effect, and physicians should be aware of this complication due to 13-cRA treatment. (SKINmed. 2021;19-.The skin is a cutaneous paper, more precisely "the paper of self," which covers the entire body. Origami is the art of paper-folding. SKIN and ORIGAMI, beyond the word play around paper, are similar in several respects-the polygonal network, the basic folds, and pleat folding. The idea of producing
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