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This study aims to demonstrate the effect of subcutaneous injections of abatacept on the histology of testes in mice. The study included 20 male BALB/c mice (average weight, 25 g; aged 12-14 weeks). Ten mice received subcutaneous (SC) injections of abatacept [0.25 mg per 25 g body weight per 0.03 mL normal saline (NS)] at zero, two, four and eight weeks. As the control group, 10 mice received SC injections of NS (0.03 mL). At the post-injection 10 week, the mice were sacrificed, and histopathological studies were conducted. The results
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