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The causative factors and pathogenesis of food allergy (FA) is not fully understood yet. Cold stress (CS) occurs frequently in human life that influences physiological activities in the body. In this study, we aimed to investigate the chronic CS (CS) effects on promoting the expression of IL-33 in intestinal epithelial cells. CS was carried out by placing mice at 4°C for 1h daily for 7 consecutive days. We developed a mouse model used to test the effects of CS on the FA development. We found that, similar to conventional FA mouse model
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