https://www.selleckchem.com/pr....oducts/bozitinib.htm
This has broad implications for understanding gating mechanisms of EAG, and related ERG and ELK channels, and places the PAS domain as a new target for drug discovery in EAG and related channels. Upregulation of EAG channel activity is linked to cancer and neurological disorders. Our study raises a possibility of repurposing the antipsychotic drug chlorpromazine for treatment of neurological disorders and cancer. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.The stringent response (SR) is
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