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A scoring system based on these three prognostic factors classified the patients into three prognostic subgroups (scores of 0-1, 2-3, and 4). The median survival of patients with scores of 0-1, 2-3 and 4 was 14, 5 and 2 mo, respectively (P less then 0.001). Subgroup analysis showed that there were significant differences in prognosis among the groups. Score 2-3 vs 0-1 hazard ratio (HR) = 2.050, 95%CI 1.363-3.083; P = 0.001; score 4 vs 0-1 HR = 3.721, 95%CI 2.225-6.225; P less then 0.001; score 2-3 vs 4 HR = 0.551, 95%CI 0.374-0.812; P =
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