https://www.selleckchem.com/pr....oducts/peficitinb-as
The ability of tSMS to modulate neuronal activities in the remote cortex could expand the possibility of its clinical use. Although tolerance serves as a major limitation in the long-term clinical use of opioids in patients with chronic severe pain, mechanisms of opioid tolerance are poorly understood. In this study, a morphine tolerance model was established by subcutaneously injecting male rats with morphine (10 mg/kg) twice a day for 10 consecutive days. In addition, a subset of morphine-tolerant rats underwen
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