https://fty720antagonist.com/h....ands-only-cardiopulm
Mechanistic researches revealed that perforin specifically regulates intrinsic IFN-γ production in CD4 T cells, maybe not CD8 T cells. We discovered that CD4 T cell depletion decreases liver damage and ameliorates the swelling and metabolic morbidities in Prf-/- mice. Moreover, improved liver attributes in HFD Prf-/- and IFN-γR-/- double knockout mice confirmed that IFN-γ is an integral element for mediating perforin regulation of NAFLD progression
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