https://www.selleckchem.com/pr....oducts/skf38393-hcl.
Surprisingly, the single-point V711A mutation we introduced rapidly reverted. In addition, qRT-PCR and Western blot confirmed that the mutations in the RdRp domain significantly affected the replication of the virus. Taken together, these results show that R543K substitution in the RdRp domain impairs the in vivo growth of TMUV, but sustaining its attenuated infectivity requires the concurrent presence of the V711A mutation.The circadian clock coordinates biological and physiological functions to day/night cycles. The perturbation
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