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Leukemia will be modeled in the mice only if we are able to target the right cancer-initiating cell with a precise given oncogene. In the last years, some examples have already started to appear in the literature showing that targeting oncogene expression to the stem cell compartment in model mice might be the correct way of reproducing the genotype-phenotype correlations found in human leukemias (Garcia-Ramirez et al., EMBO J 37(14)298783, 2018; Martin-Lorenzo et al., Cancer Res 78 (12669-2679, 2018; Perez-Caro et al., EMBO J 28(1)8-20, 2009; Rodriguez-H
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