https://www.selleckchem.com/pr....oducts/glutathione.h
Both mutation in Parkin (p = 0.0014) and LOH (p = 0.014 were significantly associated with loss of Parkin expression. Additionally, Parkin mutations were not associated with the clinicopathological parameters of the patients. Furthermore, both, LOH in Parkin and Parkin expression were significantly correlated with different clinicopathological variables (p less then 0.05). CONCLUSION Our results indicate that Parkin expression is not regulated by a single mechanism, but both mutation and LOH contribute to loss of Parkin expression
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