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6; 95% confidence interval [CI] 3.9-11.2; = 4.0e-11), but also within non- cases (n = 27; OR 5.3; 95% CI 1.9-14.5; = 0.0014). This finding suggests genetically -independent effects of SCAF4 on fALS susceptibility. Furthermore, carriage of an 18T allele was associated with a 26-month reduction in survival time (95% CI 6.6-40.8; = 0.014), but did not affect age at onset of disease. The findings in this fALS cohort suggest that rs573116164 could have -independent and broader relevance in ALS, warranting further investigation in other fALS a
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