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BACKGROUND Organisms can be primed by metabolic exposures to continue expressing response genes even once the metabolite is no longer available, and can affect the speed and magnitude of responsive gene expression during subsequent exposures. This "metabolic transcriptional memory" can have a profound impact on the survivability of organisms in fluctuating environments. SCOPE OF REVIEW Here I present several examples of metabolic transcriptional memory in the microbial world and discuss what is known so far regarding the underlying mech
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