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675 and 0.715, respectively. Combined analysis with postoperative carcinoembryonic antigen (CEA) level in discriminating recurrence and PD increased AUC values (POM1 0.715 and POM6 0.789). Furthermore, multivariate analysis for recurrence and PD after surgical resection showed that postoperative changes in the plasma miR21-5p level at POM1 and POM6 were independent prognostic factors (POM1 P = .03, POM6 P less then .01). The postoperative changes in plasma miR21-5p level could be a useful noninvasive biomarker for monitoring and predict
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