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Riclin is a typical succinoglycan produced by an agrobacterium isolate. Our previous investigation has revealed that oral riclin restores the islet function in type 1 diabetic mice. However, whether dietary riclin improves glycemic control in type 2 diabetes (T2D) is unknown. Here, we found that dietary riclin (20 and 40 mg/kg) for 4 weeks significantly decreased fasting blood glucose (55 and 67%), improved insulin sensitivity, and decreased insulin resistance in high-fat-diet/streptozocin (HFD/STZ)-induced T2D. Riclin reduced the prop
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