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ADHD Medication Medication is often part of an ADHD therapy program. The two most commonly used stimulant medications are dextroamphetamine and methylphenidate. Each of these has many brands and each has a different chemical make-up. Stimulants boost the levels of brain chemicals, which help send messages between neurons. are the first drugs that healthcare providers usually try for adults with ADHD. Stimulants Most doctors prescribe stimulants as their first treatment for ADHD. They increase levels of c