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We show that a A-linear map of Hilbert A-modules is induced by a unitary Hilbert module operator if and only if it extends to an ordinary unitary on appropriately defined enveloping Hilbert spaces. Applications to the theory of multiplicative unitaries let us to compute the equivalence classes of Hilbert modules over a class of C*-algebraic quantum groups. We, thus, develop a theory that, for example, could be used to show non-existence of certain co-actions. In particular, we show that the Cuntz semigroup functor takes a co-action to a
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