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T1 and SMCT1 were significantly reduced in both IBS groups, suggesting reduced colonocyte SCFA transfer. SCFA availability and transfer into the colonocytes may be important in IBS pathogenesis and should be prospectively studied.This article presents an improved equivalent-input-disturbance (EID) approach to handle unknown disturbances and plant uncertainties. The disturbances and uncertainties are treated as a lumped disturbance in an EID-based control system. The effect of the lumped disturbance is compensated by an EID estimator. A
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