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This article is protected by copyright. All rights reserved.A 38-year-old woman with type 1 diabetes, whose fasting plasma glucose levels were 500 mg/dL under 176 U/day of subcutaneous insulin injection, was admitted to our hospital. When insulin was administrated intravenously, she was able to maintain favorable glycemic control even under 24 U/day of regular insulin; indicating that subcutaneous insulin resistance (SIR) was accompanied. To choose an optimal insulin regimen, we performed subcutaneous insulin challenge tests without
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