https://www.selleckchem.com/pr....oducts/tunicamycin.h
The predicted mean plasma S-warfarin concentration and INR at steady state were almost 6 and 2times greater, respectively, in the presence of sorafenib than those for warfarin alone. The predicted S-warfarin concentrations and INR after reduction of the warfarin dose (0.5mg/day) in the presence of sorafenib were comparable to those after 3mg/day warfarin alone. The proposed population PK-PD model has the potential to predict an increase in INR quantitatively after concurrent administration of warfarin and sorafenib. The proposed pop
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