https://www.selleckchem.com/pr....oducts/CP-690550.htm
Background Graves' orbitopathy (GO) is the most common and serious manifestation of Graves' disease (GD). It is characterized by orbital inflammation and tissue remodeling. Although several GO models have been reported, most lack a full assessment or mechanistic evaluation. Here, we established a promising mouse model mimicking many aspects of human GO with a frequency of 70% and characterized the key role of T cells in the progression of GO. Methods An adenovirus expressing the human thyrotropin (TSH) receptor A subunit (Ad-TSHRA) wa
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