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Stimulants Are the Most Effective ADHD Medication For Adults Stimulants are among the most commonly prescribed prescription drugs that doctors use to treat ADHD in adults. They work by increasing levels of certain chemicals (neurotransmitters) in your brain to increase attention and reduce impulsivity. Antidepressants, such as Strattera (atomoxetine) and Wellbutrin/Zyban, and Bupropion (bupropion) can also help control ADHD. They increase the levels of norepinephrine in your br
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