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The necrosis-targetability of I-Hyp in the novel formulations was confirmed in vivo by SPECT and in vitro by autoradiography, fluorescence microscopy and histopathology. The plasma clearance of radioactivity was faster in the novel formulations. The novel I-Hyp formulations with HP-β-CD could be a suitable pharmaceutical excipient for I-Hyp for intravenous administration. The novel 131I-Hyp formulations with HP-β-CD could be a suitable pharmaceutical excipient for 131I-Hyp for intravenous administration.Cell membrane coating strategy is
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