https://www.selleckchem.com/JAK.html
Fission yeast Erh1 exists in a complex with RNA-binding protein Mmi1. Deletion of erh1 upregulates the phosphate homeostasis gene pho1, which is normally repressed by transcription in cis of a 5' flanking prt lncRNA. Here we present evidence that de-repression of pho1 by erh1∆ is achieved through precocious 3'-processing/termination of prt lncRNA synthesis, to wit (i) erh1∆ does not affect the activity of the prt or pho1 promoters per se; (ii) de-repression by erh1∆ depends on CPF (cleavage and polyadenylation factor) subunits Ctf1, Dis2, Ssu72, Swd
Мне нравится
Комментарий
Перепост
