https://www.selleckchem.com/pr....oducts/ziftomenib.ht
gold(I)-catalyzed heterocyclization/cycloaddition cascades of yne-enones and their variants were achieved by the application of bisphosphines (e.g., Cn-TunePhos), monophosphines, and our developed "Ming-Phos" as chiral ligands. Importantly, Ming-Phos ligands exhibited excellent performance in gold-catalyzed mechanistically distinct [3 + n]-cycloaddition reactions, in which the chiral sulfinamide moiety is possibly responsible for the interaction with the substrate to control enantioselectivity. Subsequently, we demonstrated that the
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