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Clonal evolution also occurs when a subset of cells leave the primary cyst to make metastases, that leads to reduced hereditary heterogeneity in the metastatic web site. Even though this procedure is noticed in man disease, experimental designs which recapitulate this procedure miss. Patient-derived cyst xenografts (PDX) have been proven to recapitulate the in-patient's original tumor's intra-tumor genetic heterogeneity, as well as its genomics and response to treatment, b
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