https://www.selleckchem.com/pr....oducts/ro5126766-ch5
The implications of PMD-related mechanisms for disease and potential therapeutic applications are also explored.Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment. Increases in strain lead to increased bone mass acquisition, whereas decreases in strain lead to a loss of bone mass. Given that mechanical stress is a regulator of bone mass and quality, it is important to understand how bone cells sense and transduce these mechanical cues into biological changes to identify druggable targets
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