https://www.selleckchem.com/pr....oducts/reversine.htm
Cardiac dysfunction is the main cause of multi-organ failure following sepsis within critical care units. The present study aimed to investigate the effects of the small molecule inhibition of cyclic GMP-AMP synthase (cGAS), RU.521, on cardiac function in mice with sepsis. Sepsis was induced in mice via intraperitoneal lipopolysaccharide (LPS) injection (10mg/kg, i.p.). Mice subsequently received 5mg/kg RU.521 within 10min form LPS injection. The cardiac function, inflammatory factor and oxidative stress of mice were examined for 24h
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