https://www.selleckchem.com/pr....oducts/ferrostatin-1
Furthermore, pretreatment of split-open collecting ducts with the synthetic agonist peptide significantly inhibits proton flux in ICs. These data suggest a tonic inhibitory role for Gpr116 in the regulation of V-ATPase trafficking and urinary acidification. Thus, the absence of Gpr116 results in a primary excretion of acid in KO mouse urine, leading to mild metabolic alkalosis ("renal tubular alkalosis". In conclusion, we have uncovered a significant role for Gpr116 in kidney physiology, which may further inform studies in other
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