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Hospital Information Systems assessment is important to ensure the quality of provided healthcare services. This research evaluates the success of the clinical information system used in the General Hospital "Asklepieio Voulas". A questionnaire was developed based on the DeLone McLean information systems success model, and used on February 2020, to record the users' opinions regarding the information system. The reliability of the questionnaire was tested by applying Cronbach's alpha analysis, descriptive statistics was calculated
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