https://www.selleckchem.com/pr....oducts/Azacitidine(V
Copyright © 2020 Manda, Rojo, Martínez-Klimova, Pedraza-Chaverri and Cuadrado.The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T cells and are implicated in the failure of immune surveillance in cancer. Reduced KCa3.1 channel activity mediates the heightened inhibitory effect of adenosine on the chemotaxis of circulating T cells
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